辦公室：上海大學寶山校區東區19号樓528室

E-mail： lshi@shu.edu.cn

個人簡介

2016年于山東大學獲得生物技術和英語雙學士學位，2019年、2022年于南京大學生命科學學院分别獲得碩士和博士學位，2022年進入上海大學從事博士後研究工作，2024.10出站。曾連續三年獲得研究生國家獎學金，并獲得2019年“南京大學學生年度人物”、2022年“南京大學優秀畢業生”、2022年“江蘇省優秀畢業生”、2023年“南京大學優秀博士學位論文”、2023年“江蘇省優秀博士學位論文”等榮譽和稱号。2022年進入上海大學生命科學學院從事博士後研究工作，獲批2022年全國“博士後創新人才支持計劃” 和2022年“上海市超級博士後”等項目。目前在SCI刊物上已正式發表23篇研究性論文，其中11篇以第一/通訊作者的身份發表在國際學術期刊上，包括J. Am. Chem. Soc.、Nano Lett.、Anal. Chem.、Biosen. Bioelectron.、ACS Appl. Mater. Interfaces等期刊，申請了5項國家發明專利、2項已授權，作為章節作者參與Elsevier邀稿專著“Nano-inspired biosensors for protein assay with clinical applications”的撰寫。

代表性論文：

1. Liu Shi, Beibei Nie, Lingjun Sha, Keqin Ying, Jinlong Li, Genxi Li. Graphene Oxide-Mediated Regulation of Volume Exclusion and Wettability in Biomimetic Phosphorylation-Responsive Ionic Gates. Nano Lett. 2023, 23: 10326-10333

2. Liu Shi, Deqi Kuang, Xuemei Ma, Mohammed Jalalah, Saeed A. Alsareii, Tao Gao, Farid A. Harraz, Jie Yang, and Genxi Li. Peptide Assembled in a Nano-confined Space as a Molecular Rectifier for the Availability of Ionic Current Modulation. Nano Lett. 2022, 22: 1083-1090

3. Liu Shi, Chaoli Mu, Tao Gao, Wenxin Chai, Anzhi Sheng, Tianshu Chen, Jie Yang, Xiaoli Zhu, and Genxi Li, Rhodopsin-Like Ionic Gate Fabricated with Graphene Oxide and Isomeric DNA Switch for Efficient Photocontrol of Ion Transport. J. Am. Chem. Soc. 2019, 141: 8239-8243

4. Liu Shi, Keqin Ying, Lingjun Sha, Yuanyuan Zhang, Lizhou Sun, Genxi Li. DNA-Peptide Interaction-Modulated Charge Reversal in Biomimetic Nanochannels for Simple and Efficient Detection of Histone Deacetylase Activity. Anal. Chem. 2024, 96: 4817–4824

5. Liu Shi, Lin Wang, Xuemei Ma, Xiaona Fang, Liangliang Xiang, Yongxiang Yi, Jinlong Li, Zhaofeng Luo, Genxi Li. Aptamer-Functionalized Nanochannels for One-Step Detection of SARS-CoV-2 in Samples from COVID-19 Patients. Anal. Chem. 2021, 93: 16646-16654

6. Liu Shi, Xuemei Ma, Haojie Xie, Yujia Qin, Yue Huang, Yuanyuan Zhang, Lizhou Sun, Jie Yang, Genxi Li. Engineering m6A demethylation-activated DNAzyme for visually and sensitively sensing fat mass and obesity-associated protein. Biosen. Bioelectron. 2023, 222: 115007

7. Liu Shi, Fengjie Jia, Lin Wang, Mohammed Jalalah, Tao Gao, Farid A. Harraz, Genxi Li. Fabrication of an artificial ionic gate inspired by mercury-resistant bacteria for simple and sensitive detection of mercury ion. Sens. Actuators B Chem. 2021, 326: 128976

8. Liu Shi, Lin Wang, Xuemei Ma, Mohammed Jalalah, Saeed A. Alsareii, Tao Gao, Farid A. Harraz, Genxi Li. Electrochemical Trans-Channel Assay for Efficient Evaluation of Tumor Cell Invasiveness. ACS Appl. Mater. Interfaces 2021, 13: 17268-17275

9. Liu Shi, Chaoli Mu, Tao Gao, Tianshu Chen, Shuang Hei, Jie Yang, Genxi Li, DNA nanoflower blooms in nanochannel: a new strategy for miRNA detection. Chem. Commun. 2018, 54: 11391-11394

10. Liu Shi, Lin Wang, Xiaomeng Yu, Deqi Kuang, Yue Huang, Nana Yang, Jie Yang, Genxi Li. Colorimetric detection of furin based on enhanced catalytic activity of G-quadruplex/hemin DNAzyme. Anal. Chim. Acta 2024, 1323: 343070

授權發明專利：

基于石墨烯蓋子與仿生DNA相互作用的高效光調節離子門控，發明專利，ZL 2018 1 1514485.0

一種基于通道内生成DNA納米花的miRNA檢測裝置，發明專利，ZL 2018 1 0453521.0

研究領域

生化分析與生物傳感